Dog Anxiety Medication

Dog Anxiety Medication

Posted on

Dog Anxiety Medication

Do I get enough magnesium?

1 Way of assessing your magnesium status is to simply touch with your Health care provider and ask detailed magnesium testing. Yet magnesium evaluation is typically done using blood chemical testing, and these tests may be misleading. Only 1% of magnesium from the body is in fact found in blood, and only.3percent is found in blood serum, so clinical blood serum testing may not successfully identify magnesium deficiency.

How to proceed?


Fortunately, it's likely to get a sense of where your intake may lie |} By simply asking yourself a few questions about your lifestyle, and seeing for certain signs and signs of low magnesium levels.

Learn how to examine your hints below, and Learn What you can do to ensure Magnesium balance and good health. these questions, you may be at risk for low magnesium intake. |} {

|} Do you drink carbonated beverages on a regular basis?

These chemicals really bind With calcium inside the digestive tract, rendering it unavailable to the body. Thus, even if you're eating a balanced diet, by drinking soda along with your meals you're flushing magnesium from your system. 4 6

The average consumption of carbonated beverages now is greater than ten times What it had been in 1940. 7 This skyrocketing increase is accountable for the two decreased magnesium and calcium availability in the body. {8 9

|} Do you regularly eat pastries, cakes, desserts, candies or other sweet foods?

Processed sugar Isn't only a zero magnesium merchandise but in Addition, It induces the Body to excrete magnesium throughout the kidneys. practice of producing refined sugar from sugar cane removes molasses, stripping the magnesium content entirely. |}

And glucose does not just serve to reduce magnesium levels. Sweet foods are Known by nutritionists as"anti-nutrients". |} Anti-nutrients like candies are foods which replace whole nutritious foods from the diet, yet really consume nutrients when digested, resulting in a net loss. Since all foods require minerals and vitamins to be consumed in order to power the process of digestion, it's important to select foods which"back" vital nutrients, and then some.

The sweet foods and processed baked products you have on your diet, the More likely you're deficient in magnesium and other nutrients that are essential. {

|} Do you experience a great deal of stress on your life, or have you recently had a significant medical procedure such as surgery?

Both physical and psychological stress may be cause of magnesium deficiency.


Anxiety may be cause of magnesium deficiency, and a lack of magnesium tends |} To magnify the pressure response, worsening the problem. In studies, cortisol and adrenaline, byproducts of this"fight or flight" reaction related to tension and stress, were correlated with decreased magnesium. 10

Because stressful conditions require more magnesium use by your system, all Such conditions may cause deficiency, including both psychological and physical types of stress such as surgery, burns, and chronic disease. {

|} Do you drink tea, coffee, or other caffeinated drinks daily?

Magnesium levels are controlled in the body in large part from the kidneys, Which filter and excrete excess magnesium and other nutritional supplements. But caffeine causes the kidneys to release additional magnesium regardless of body position.

If you drink caffeinated beverages such as coffee, soda and tea regularly, Your risk for magnesium deficiency is raised. |} {

|} {Do you take a diuretic, heart medication, asthma drugs, birth control pills or estrogen replacement therapy? |}

The effects of certain drugs have been demonstrated to reduce magnesium levels in The entire body by raising magnesium loss through excretion from the kidneys.

See also:

For a complete list of the specific drugs that can influence magnesium levels, read our article, Reasons For a Lack of Magnesium. {
|} {Do you drink more than seven alcoholic beverages each week? |}

The Impact of alcohol on magnesium levels is like the impact of Diuretics: it lowers magnesium available to the cells by increasing the excretion of magnesium from the kidneys. In research, the clinical magnesium deficiency was found in 30% of alcoholics. 11

Increased alcohol intake also results in diminished efficiency of this Digestive system, as well as vitamin D deficiency, each of which may give rise to low magnesium levels. {12

|} Do you take calcium supplements with no calcium or magnesium supplements with magnesium in under a 1:1 ratio?

Studies have shown that if magnesium intake is reduced, calcium Supplementation may reduce magnesium absorption and retention. 13 14 15 And, whereas calcium supplementation may have adverse consequences on magnesium levels, magnesium supplementation really boosts the body's utilization of calcium. 16


Though many reports indicate taking calcium to magnesium in a 2:1 ratio, this |} Figure is mostly random. The perfect ratio for any person will vary based on current conditions as well as risk factors for deficiency.

But, several researchers today support a 1:1 calcium to magnesium ratio For enhanced bone support and decreased risk of disorder. That is due not only to the higher signs pointing to widespread magnesium deficiency, but also concerns over the risk of cardiovascular calcification when low magnesium stores are coupled with higher calcium consumption.

READ  Vitamin D3 For Anxiety & Depression


As stated by mentioned magnesium researcher Mildred Seelig:|}

The body tends to keep calcium when within an magnesium-deficient state. Extra Calcium intake in this time could result in an abnormal rise of calcium levels inside the cells, including the cells of the heart and blood vessels... Given the delicate balance required between calcium and magnesium in the cells, so it is ideal to make sure magnesium is sufficient if you're taking calcium supplements." {17

|} Do you encounter any of the following:

Stress? {
Times of hyperactivity?
|} {
Difficulty getting to sleep?
|} {
Difficulty staying asleep?

The above symptoms may be neurological signs of magnesium deficiency. Adequate magnesium is essential for nerve conduction and is also associated with electrolyte imbalances which affect the nervous system. Low magnesium is also connected with personality changes and sometimes depression.

Read more:

For a complete list of the signs of magnesium deficiency, read our article, Symptoms of Vitamin . {
|} {Do you encounter any of the following:

Painful muscle spasms? |} {
Muscle cramping?
|} {
Facial tics? {
Eye twitches, or involuntary eye movements?
|} {

Neuromuscular symptoms such as these are among the classic signs of a |} Potential magnesium shortage.

Without magnesium, our muscles would be in a constant state of contraction.

Magnesium is a required element of muscular relaxation, and with no our Muscles are in a constant state of contraction. deal with. |} As mentioned in the publication The Magnesium Factor, the two minerals are"two sides of a physiological coin; they've activities that oppose one another, yet they serve as a group." 18


Chvostek's Sign and Trousseau's Sign are both clinical tests for involuntary |} Muscle moves, and both may indicate either magnesium or calcium deficiency, or both. In reality, magnesium deficiency may actually seem like calcium deficiency in analyzing, and among the first recommendations upon getting low calcium evaluation results is magnesium supplementation.

Read more:

For a complete list of the ailments associated with magnesium deficiency, read our article, Symptoms of Vitamin .
To learn more about the role of calcium in muscular function, see The Way Magnesium Works in the Body. {
|} Can you answer yes to any of the above questions and are also age 55 or older? |}

Older adults are particularly vulnerable to low magnesium status. |} It has Been shown that aging, stress and disease all contribute to growing magnesium needs, yet most older adults really take in less magnesium from food sources compared to if they were younger.

Additionally, magnesium metabolism may be less efficient as we grow older, as Changes the GI tract and kidneys contribute to older adults consuming less and retaining less magnesium. 19

If You're above 55 and also showing lifestyle signs or symptoms related to Low magnesium, it's particularly important that you work to improve your magnesium intake. When body stores of magnesium run low, risks of overt hypomagnesaemia (magnesium deficiency) increase appreciably.

How do you know for sure if you have a deficiency? {

Magnesium's effect is so crucial and far reaching that symptoms of its own |} Absence reverberate through the body's systems. {This makes signs of its absence hard to pin down with complete precision, even for cutting edge researchers. |} Physicians Pilar Aranda and Elena Planells reported this difficulty in their report in the International Magnesium Symposium of 2007:


The clinical manifestations of magnesium deficiency are difficult to define |} Because depletion of this cation is associated with considerable abnormalities in the metabolism of several elements and enzymes. If prolonged, inadequate magnesium intake may be responsible for symptoms caused by other ailments, or whose causes are unknown."

One of investigators, magnesium deficiency is Called the silent epidemic of Our times, and it's widely acknowledged that definitive proof for deficiency remains elusive. {Judy Driskell, Professor, Nutrition and Health Sciences in the University of Nebraska, refers to this"invisible deficiency" as chronic latent magnesium deficiency, and explains:


Normal plasma and serum magnesium concentrations have been found in Individuals with low magnesium in [red blood cells] and cells. |} Yet efforts to find an index of subclinical magnesium status haven't yielded a cost-effective one that's been well validated." 20

Yet while the identification of magnesium deficiency may be uncertain, its Importance is undeniable.


Magnesium triggers over 300 enzyme reactions in the body, translating to |} Tens of thousands of biochemical reactions happening on a constant basis daily. essential to nerve transmission, muscle contraction, blood coagulation, energy production, nutrient metabolism and bone and cell formation. |}

Contemplating these varied and sour consequences, and of course the Cascading influence magnesium levels have on other vital minerals such as calcium and potassium, 1 thing is clear -- long term low magnesium consumption is something to be avoided.

What do you do to increase magnesium intake?

The longer your intake stays low, the greater likelihood your physical stores Will be diminished, leaving you exposed to some of the troubling side effects of long-term deficiency. Based on Dr. Carolyn Dean, M.D., N.D., and expert on magnesium treatment, sufficient magnesium may enhance heart health, prevent stroke and obesity, and enhance mood and memory.

READ  Best Gaba Supplement Uk

If you answered no to all of the above questions, you may be able to rely on High food sources of magnesium, such as those described in our article on Magnesium at the Diet.

Yet for a Lot of People, especially those with diseases And symptoms associated with reduced magnesium, active magnesium supplementation may be a crucial part of returning to good health.


In her publication, The Magnesium Miracle, Dr. Dean notes that achieving |} Adequate magnesium is notoriously hard, saying:

I'm convinced that to get enough magnesium now, you need to take Supplements" 21

One of the Very Best ways to improve your magnesium levels is to unite A healthy diet using transdermal magnesium. |}

Lots of the variables that contribute to reduced magnesium shops Are brought on by inefficiencies of their GI tract. By providing magnesium via the skin directly into the cells, topical magnesium products bypass lots of the problems connected with reduced magnesium absorption.

In older adults, decreased gastric acid levels in the Digestive system may be a factor in decreased mineral availability. Hydrochloric acid supplements may be combined with magnesium to fight this dilemma; however a simpler and less costly option is the use of magnesium supplements. Magnesium chloride has been proven to have a higher bioavailability, while simultaneously giving the chloride necessary for healthy digestion and vitamin and nutrient absorption.

Magnesium researcher Mildred Seelig has called magnesium"the quiet Ability of our hearts and arteries" and"essential for life". |} complete health". |}

In Case You Haven't heard much about magnesium and its significance to good health, Now is the opportunity to learn. And if it's something you've always meant to look into, now's the time to do it!


Leg cramps Are reported in up to 60% of adults and 7 percent of kids.1 They are troublesome and can cause severe pain and sleep disturbance,2 and residual pain occasionally happens in the affected muscles following cramping.3 Up to 20 percent of people who complain of leg cramps have symptoms daily that are severe enough to need medical intervention.1Currently no remedies for leg cramps are proven to be safe and effective1 but there is a clear demand for treatment options.

Quinine has Been commonly utilized to treat leg cramps but TGA approval for this indication was withdrawn in 2004 following reports of an increased risk of thrombocytopenia and 4 associated fatalities in Australia.4

Since Magnesium plays a role in neuromuscular transmission and muscle contraction, it has been hypothesised that magnesium deficiency may predispose to muscular cramps.2,5Hence magnesium supplements are usually recommended to prevent cramps. Does the evidence support using magnesium for this indication?

Practice points

Differentiating leg cramp from other ailments can be challenging, the expression'cramp' may be employed to describe many different pain types. {
When choosing a medical history, consider factors which may account for leg cramp (peripheral vascular disease or motor neurone disease) as well as medication causes (calcium-channel blockers, angiotensin II-receptor antagonists and diuretics). |}
Whilst magnesium deficiency has been proposed as a cause of leg cramps, there is no evidence that magnesium supplements offer a clinical benefit other than for pregnancy-related leg cramp.
Consider the potential for development of hypermagnesaemia in patients taking magnesium supplements, particularly in older people and people with kidney disease. {
Magnesium disagrees with bisphosphonates and tetracycline antibiotics and should be taken 2 hours before or after these medicines. |}
Do not prescribe quinine tablets for leg cramps. The efficacy of quinine in preventing cramp is limited and can be outweighed by the risk of severe thrombocytopenia, which may be deadly.
Contemplate non-pharmacological interventions for cramps such as stretching.

Diagnosis: concentrate on treatable causes

Differentiating Leg cramps from some other conditions in older people can be challenging, the expression'cramp' may be employed to describe many different pain types. {Consider other causes such as restless legs syndrome, nocturnal myoclonus, myopathic and neuropathic conditions.3


When taking A patient's medical history comprise a review of medicines and medical ailments.1 Consider other variables which may contribute, such as peripheral vascular disease or motor neurone disease. Potential medication causes of cramp include calcium-channel blockers, angiotensin II-receptor antagonists and diuretics.3 Lately, the calcium-channel blockers diltiazem and verapamil are evaluated for the treatment of muscle cramp in older people, however the trials were small and of poor quality.6,7


Physical Examination rarely identifies leg cramps because they're misaligned, irregular, and generally occur at night. But findings on evaluation may indicate a potential underlying medical cause (i.e.peripheral cardiovascular disease).1,5

There are no Routine blood tests recommended for the identification of muscular cramps and there's no proven association with electrolyte abnormalities.8

The third Trimester of pregnancy is often associated with leg cramps, although it is hard to distinguish between pregnancy as the primary cause and venous insufficiency.9 Despite the high incidence of leg cramps during pregnancy, there has been minimal research in this area.

Do not use quinine tablets for leg cramp

Treatment With quinine was common before its withdrawal as a sign in 2004. The withdrawal was a consequence of 198 reports of thrombocytopenia related to quinine use (since 1972), including 4 deaths.4 Quinine was withdrawn at a similar period in america and afterwards, in 2006, the US FDA Federal Register alerted consumers to the problems surrounding off-label use, reporting 665 serious adverse events including 93 deaths since 1969.10 Despite this, off-label use still proceeds both here4 and overseas.

READ  Natural Ways To Reduce Anxiety While Pregnant

Magnesium treatment for leg cramps

Proof is missing except for pregnancy-associated cramps

The Effectiveness and safety of magnesium has been established for eclampsia and pre-eclampsia, arrhythmia, severe asthma, and migraine.11 There is some evidence for efficacy of magnesium supplementation in treating leg cramps in pregnant women but not for other people.2,12

A recent Systematic review assessed the impact of magnesium versus placebo for the treatment of nocturnal leg cramps and found the overall effect of magnesium to be insignificant.2 Seven trials were included, one evaluated calcium extract versus placebo and the remainder evaluated oral magnesium treatment but dose and frequency of treatment varied involving all studies.

A Sub-analysis of three of the studies involving only pregnant women revealed a significant gap between the magnesium and placebo groups in the median number of leg cramps experienced per week.2 Nevertheless the studies simply contained a small number of participants (n=361 in complete and n=198 from the subgroup analysis), and therefore was underpowered to detect significant differences between groups. Additionally selection bias may have impacted results as participants were included in the analysis whose leg complaints may have been confused with ailments not known to be associated with magnesium deficiency (i.e. restless leg syndrome).

Another Recent systematic review assessed a further seven studies in patients with leg treated with magnesium.12 The elemental magnesium dose given varied between studies. The populations included 322 mostly older patients and 202 women with pregnancy-associated leg cramps. |} After four weeks of therapy, differences in percent change from baseline of cramps each week between magnesium and placebo groups were modest and not statistically significant.

The writers Concluded that magnesium is not likely to offer a significant benefit in reducing the frequency or severity of idiopathic leg cramps in older people.12 The second review also included three additional studies on pregnant women; although a meta-analysis wasn't possible with them, results in the individual studies were considered and found to be more combined. 1 study discovered calcium decreased cramp frequency and pain whereas the other two found no benefit.12 Although two of the studies were comparable in design and setting,13,14 their outcomes were different; this may have been because one of the studies lacked baseline dimension of cramp frequency. If cramp frequency before intervention wasn't comparable between participants in those studies, it isn't appropriate to compare the number of cramps experienced during the treatment period.

Oral magnesium supplementation is well taken

The two {Meta-analyses found that magnesium is well taken with the most frequent adverse effects affecting the digestive system (diarrhoea, nausea, vomiting, flatulence and constipation).2,12


Moderate-to-severe {And symptomatic hypermagnesaemia is generally as a result of excess supplemental intake of magnesium (e.g. as antacids, enemas or by intravenous infusion), most often in patients with kidney impairment. |} Be aware of the most common clinical features of moderate-to-severe hypermagnesaemia that are usually neuromuscular (e.g. loss of deep tendon reflexes, muscular paralysis, depressed conscious state and respiratory depression). nausea, anorexia, skin flushing, hypotension, bradycardia/heart block and cardiac arrest.15


When Contemplating magnesium supplements, ensure patients take a product containing magnesium only. Some magnesium supplements have been blended with potassium and may contribute to hyperkalaemia in people taking ACE inhibitors or other medications that cause potassium retention.3 Consider assessing liver function in people using medicines that may impair or adversely affect kidney function16 and watch for signs of toxicity.15

Other therapies

Small research Have demonstrated some benefit from other medications including diltiazem, gabapentin and vitamin B complex although none may be recommended for muscular cramps because of the inadequate quality of evidence.6,17-19 Multivitamins and sodium supplementation also have demonstrated benefit in preventing cramps in pregnant women, although consider the potential risk of hypertension using sodium supplementation.9 Australian guidelines recommend calcium supplements for leg cramps in pregnant women according to case reports but also highlight there are no controlled trials to support its use.20 Paracetamol may be handy to manage residual muscle pain following cramping.3

Non-pharmacological treatment

Passive Stretch and massage of the affected muscle may relieve cramp and extending the calf muscles daily has been advocated to prevent cramp.21 Though there's no clinical trial evidence to support these measures, anecdotal evidence indicates they may be effective and the risk of adverse effects is reduced.

Information for patients


Magnesium interacts with other medications |}


Magnesium considerably reduces the absorption of oral bisphosphonates and tetracycline antibiotics and may lower their activity. |} {
Advise patients to ensure they take these medicines at least 2 hours before or after taking a magnesium supplement.22 |}

Median Amount of leg cramps experienced per week: Difference = 0.807 (CI 0.015 to 1.207)
Difference In percentage change from baseline of cramps per week: Difference = --3.93percent (CI |} --21.12percent to 13.26%)