What Is The Best Anxiety Medication For Dogs

What Is The Best Anxiety Medication For Dogs

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What Is The Best Anxiety Medication For Dogs

Do I get enough magnesium?

1 Way of assessing your magnesium standing is to simply touch with your Health care provider and ask detailed magnesium testing. Yet magnesium assessment is typically done using blood chemical testing, and these tests can be misleading. Just 1% of magnesium from the body is actually found in blood, and just.3% is found in blood serum, therefore clinical blood serum testing might not successfully identify magnesium deficiency.

What to do?


Fortunately, it's likely to get a sense of where your intake may lie |} Simply by asking yourself a few questions about the way you live, and watching for certain signs and signs of low sodium levels.

Discover how to read your hints below, and Learn What you can do to ensure Magnesium balance and good health. If you answer yes to any of the following questions, you might be at risk for low calcium consumption. |} {

|} Do you drink carbonated drinks on a regular basis?

These chemicals really bind With calcium within the digestive tract, rendering it unavailable to the body. Thus, even when you're eating a balanced diet, by drinking soda with your foods you're flushing out magnesium out of your system. 4 5 6

The average consumption of carbonated drinks today is greater than ten times What it had been in 1940. 7 This skyrocketing increase is accountable for the two decreased calcium and magnesium availability in the body. {8 9

|} Do you regularly eat pastries, cakes, desserts, candies or other sweet foods?

Processed sugar is not only a zero magnesium product but in Addition, It induces the Body to excrete magnesium through the kidneys. practice of producing refined sugar from sugar cane removes molasses, stripping the magnesium content entirely. |}

And sugar does not just serve to reduce magnesium levels. Sweet foods are Known by nutritionists as"anti-nutrients". |} Anti-nutrients like sweets are foods that replace whole nutritious foods from the diet, nevertheless really consume nutrients when digested, causing a net loss. Since all foods require minerals and vitamins to be consumed as a way to power the process of nourishment, it's important to select foods that"put back" vital nutrients, and then a few.

The sweet foods and processed baked goods you have on your diet, the More likely you're deficient in magnesium and other nutrients that are essential. {

|} Do you experience a lot of stress on your life, or maybe you have recently had a major medical procedure such as surgery?

Both physical and psychological stress may be cause of magnesium deficiency.


Anxiety may be cause of magnesium deficiency, and a lack of magnesium tends |} To magnify the pressure response, worsening the problem. In studies, cortisol and adrenaline, byproducts of the"fight or flight" reaction associated with stress and stress, were correlated with magnesium. 10

Because stressful conditions demand more calcium use by the body, all Such conditions may lead to lack, including both physical and psychological types of stress such as surgery, burns, and chronic illness. {

|} Do you drink coffee, tea, or other caffeinated drinks daily?

Magnesium levels are regulated in the body in large part by the kidneys, Which filter and excrete excess magnesium and other nutritional supplements. But caffeine causes the kidneys to release extra magnesium irrespective of body status.

If you drink caffeinated beverages such as coffee, soda and tea frequently, has been raised. |} {

|} {Do you take a diuretic, heart medicine, asthma medication, birth control pills or estrogen replacement therapy? |}

The effects of certain drugs have been demonstrated to reduce magnesium levels in The entire body by raising magnesium reduction through excretion by the kidneys.

See also:

For an entire list of the specific drugs which could influence magnesium levels, read our post, Causes of a Lack of Magnesium. {
|} {Do you drink more than seven alcoholic drinks per week? |}

The Impact of alcohol on magnesium levels is similar to the impact of Diuretics: it lowers magnesium readily available to the cells by increasing the excretion of magnesium by the kidneys. In research, the clinical calcium deficiency has been found in 30 percent of alcoholics. 11

Higher alcohol intake also contributes to diminished efficiency of the Digestive system, as well as vitamin D deficiency, both of which can give rise to low magnesium levels. {12

|} Do you take calcium supplements with no magnesium or calcium supplements with magnesium in under a 1:1 ratio?

Studies show that if magnesium intake is reduced, calcium Supplementation may reduce magnesium absorption and retention. 13 14 15 And, whereas calcium supplementation can have negative effects on magnesium amounts, magnesium supplementation really boosts the body's use of calcium. 16


Though many reports suggest taking calcium to magnesium in a 2:1 ratio, this |} Figure is largely arbitrary. The perfect ratio for any person will vary depending on current conditions as well as risk factors for lack .

But, several researchers now support a 1:1 calcium to magnesium ratio For improved bone support and decreased risk of disorder. That is due not just to the increased signs pointing to widespread magnesium deficiency, but also concerns over the danger of arterial calcification when low magnesium shops are coupled with higher calcium intake.

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As stated by noted magnesium researcher Mildred Seelig:|}

The body tends to retain calcium when in a magnesium-deficient condition. Extra Calcium intake at this time can cause an abnormal growth of calcium levels within the cells, including the cells of the heart and blood vessels... Given the delicate balance necessary between calcium and magnesium in the cells, so it is best to be sure magnesium is adequate if you're taking calcium supplements" {17

|} Do you experience any of these:

Anxiety? {
Times of hyperactivity?
|} {
Difficulty getting to sleep?
|} {
Difficulty staying asleep?

The above symptoms could be neurological signs of magnesium deficiency. Adequate magnesium is essential for nerve conduction and is also related to electrolyte imbalances that affect the nervous system. Low magnesium can also be connected with character changes and sometimes depression.

Read more:

For a complete list of these Symptoms of magnesium deficiency, read our post, Symptoms of Low Magnesium. {
|} {Do you experience any of these:

Painful muscle spasms? |} {
Muscle cramping?
|} {
Facial tics? {
Eye twitches, or involuntary eye movements?
|} {

Neuromuscular symptoms such as these are among the classic signs of a |} Possible magnesium shortage.

Without magnesium, our muscles would be in a continuous state of contraction.

Magnesium is a required element of muscle relaxation, and without it our Muscles would be in a continuous state of regeneration. deal with. |} As noted in the book The Magnesium Factor, both minerals are"two sides of a real life coin; they've actions that oppose one another, yet they serve as a group." 18


Chvostek's Sign and Trousseau's Sign are both clinical evaluations for involuntary |} Muscle moves, and both may indicate either calcium or magnesium deficiency, or both. In reality, magnesium deficiency might actually seem like calcium deficiency in testing, and one of the first recommendations on getting low calcium test results is magnesium supplementation.

Read more:

For a complete list of the ailments associated with magnesium deficiency, read our post, Symptoms of Low Magnesium.
To learn more about the role of calcium in muscular function, visit How Magnesium Functions in the Body. {
|} Can you answer yes to any of the above questions and are also age 55 or older? |}

especially vulnerable to low magnesium status. |} It's Been proven that aging, stress and illness all contribute to growing magnesium needs, yet most older adults really take in less magnesium from food resources compared to if they were younger.

Additionally, magnesium metabolism may be less effective as we grow older, as Affects the GI tract and kidneys contribute to older adults absorbing less and retaining less magnesium. 19

If You're above 55 and also showing lifestyle signs or symptoms related to Low magnesium, it's particularly important that you work to improve your calcium consumption. When body stores of magnesium run low, dangers of overt hypomagnesaemia (magnesium deficiency) grow significantly.

How can you know for certain if you have a lack? {

Magnesium's impact is so crucial and far reaching that symptoms of its |} Absence reverberate through the body's systems. {This makes signs of its lack hard to pin down with complete precision, even for cutting edge researchers. |} Physicians Pilar Aranda and Elena Planells reported this difficulty in their report in the International Magnesium Symposium of 2007:


The clinical manifestations of magnesium deficiency are difficult to define |} Because depletion of this cation is related to significant abnormalities in the metabolism of several enzymes and elements. If prolonged, inadequate magnesium intake might be liable for symptoms attributed to other causes, or whose causes are unknown."

Among investigators, magnesium deficiency is known as the silent epidemic of Our instances, and it's widely acknowledged that definitive proof for lack remains elusive. {Judy Driskell, Professor, Nutrition and Health Sciences in the University of Nebraska, describes this"invisible deficiency" as chronic latent magnesium deficiency, and clarifies:


Normal serum and plasma magnesium concentrations have been found in People with low magnesium in [red blood cells] and tissues. |} Yet attempts to discover an index of subclinical magnesium standing haven't yielded a cost-effective one that has been well validated." 20

Yet while the identification of magnesium deficiency may be uncertain, its Importance is undeniable.


Magnesium activates over 300 enzyme reactions in the body, translating to |} Tens of thousands of biochemical reactions occurring on a continuous basis daily. essential to nerve transmission, muscle contraction, blood coagulation, energy production, nutrient metabolism and bone and cell formation. |}

Considering these varied and sour effects, and of course the Cascading effect magnesium levels have on other important minerals such as potassium and calcium, 1 thing is clear -- long duration low magnesium intake is something to be avoided.

What can you do to increase magnesium intake?

The more your intake stays low, the greater likelihood your physical stores Will be diminished, leaving you vulnerable to some of the troubling side effects of long-term deficiency. According to Dr. Carolyn Dean, M.D., N.D., and expert on magnesium therapy, adequate magnesium can improve heart health, prevent stroke and obesity, and improve mood and memory.

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If you answered no to all of the above questions, you may Have the Ability to rely on High food sources of magnesium, like those described in our post on Magnesium in the Diet.

Yet for many people, especially individuals with ailments And symptoms related to reduced magnesium, active magnesium supplementation could be a crucial element of returning to good health.


In her book, The Magnesium Miracle, Dr. Dean notes that achieving |} Adequate magnesium is notoriously hard, stating:

I'm convinced that to have enough magnesium today, you need to take Supplements" 21

One of the Very Best ways to improve your magnesium levels would be to unite A wholesome diet with transdermal magnesium. |}

Many of the factors which contribute to reduced magnesium stores Are brought on by inefficiencies of the GI tract. By providing magnesium through the skin directly into the cells, topical magnesium products skip lots of the problems connected with reduced magnesium absorption.

In older adults, decreased gastric acid amounts in the Digestive system might be a element in decreased mineral availability. Hydrochloric acid supplements might be combined with magnesium to combat this problem; however a simpler and less expensive choice is the use of magnesium supplements. Magnesium chloride has been proven to have a high bioavailability, while concurrently giving the chloride necessary for healthy digestion and vitamin and mineral absorption.

Magnesium researcher Mildred Seelig has known as magnesium"the silent Ability of our hearts and arteries" and"essential for life". |} complete health". |}

If you haven't heard much about magnesium and its significance to good health, Now's the opportunity to learn. And when it's something you've always intended to check into, now's the time to take action!


Leg cramps Are reported in up to 60% of adults and 7 percent of children.1 They are troublesome and can cause severe pain and sleep disturbance,2 and residual pain sometimes occurs in the affected muscles after cramping.3 Up to 20 percent of individuals who complain of leg cramps have symptoms daily which are severe enough to require medical intervention.1Currently no remedies for leg cramps are clinically proven to be safe and effective1 but there's a clear demand for treatment choices.

Quinine has Been commonly used to treat leg cramps but TGA approval for this sign was withdrawn in 2004 after reports of an increased probability of thrombocytopenia and 4 related deaths in Australia.4

Since Magnesium plays a role in neuromuscular transmission and muscle contraction, it has been hypothesised that magnesium deficiency may predispose to muscular cramps.2,5Thus magnesium supplements are usually recommended to prevent cramps. Does the evidence support using magnesium for this sign?

Practice points

Differentiating leg cramp from different ailments can be hard, the term'cramp' can be used to describe a variety of pain types. {
When choosing a medical history, think about factors that might account for leg cramp (peripheral vascular disease or motor neurone disease) as well as medication causes (calcium-channel blockers, angiotensin II-receptor antagonists and diuretics). |}
Whilst magnesium deficiency has been proposed as a cause of leg cramps, there's no evidence that magnesium supplements offer a clinical advantage other than for pregnancy-related leg cramp.
Think about the capacity for development of hypermagnesaemia in patients using magnesium supplements, particularly in older people and individuals with kidney disease. {
Magnesium interacts with bisphosphonates and tetracycline antibiotics and should be taken 2 hours before or after these medications. |}
Do not prescribe quinine tablets for leg cramps. The efficacy of quinine in preventing cramp is limited and is outweighed by the risk of severe thrombocytopenia, which might be deadly.
Consider non-pharmacological interventions for cramps such as stretching.

Diagnosis: concentrate on treatable causes

Differentiating Leg cramps from other conditions in older individuals can be hard, the term'cramp' can be used to describe a variety of pain types. {Consider other causes such as restless legs syndrome, nocturnal myoclonus, myopathic and neuropathic conditions.3


When taking A patient's medical background comprise a review of medications and medical ailments.1 Consider other factors which might contribute, such as peripheral vascular disease or motor neurone disease. Potential medication causes of cramp include calcium-channel blockers, angiotensin II-receptor antagonists and diuretics.3 Lately, the calcium-channel blockers diltiazem and verapamil have been assessed for treating muscle cramp in older individuals, however the trials were small and of inferior quality.6,7


Physical Examination rarely identifies leg cramps because they are involuntary, unpredictable, and generally occur at night. But findings on examination may indicate a possible underlying medical cause (i.e.peripheral vascular disease).1,5

There are no Regular blood tests recommended for the diagnosis of muscle cramps and there is no proven association with electrolyte abnormalities.8

The third Trimester of pregnancy is frequently related to leg cramps, although it is hard to distinguish between pregnancy as the primary cause and venous insufficiency.9 Despite the high prevalence of leg cramps in pregnancy, there has been minimal research in this region.

Do not use quinine tablets for leg cramp

Treatment With quinine was common before its withdrawal as a sign in 2004. The withdrawal was a consequence of 198 reports of thrombocytopenia associated with quinine use (since 1972), including 4 deaths.4 Quinine was withdrawn at a similar time in the US and subsequently, in 2006, the US FDA Federal Register alerted consumers to the problems surrounding off-label use, reporting 665 serious adverse events including 93 deaths since 1969.10 Despite this, off-label use still proceeds both here4 and abroad.

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Magnesium treatment for leg cramps

Proof is lacking except for pregnancy-associated cramps

The Effectiveness and security of magnesium has been established for eclampsia and pre-eclampsia, arrhythmia, severe asthma, and migraine.11 There is some evidence for efficacy of magnesium supplementation in treatment of leg cramps in elderly women but not for different people.2,12

A recent Systematic review assessed the impact of magnesium versus placebo for the treatment of nocturnal leg cramps and found the general effect of magnesium to be insignificant.2 Seven trials were included, one assessed magnesium infusion versus placebo along with the remainder assessed oral magnesium therapy but dose and frequency of therapy varied involving all studies.

A Sub-analysis of three of the research involving just pregnant women showed a substantial difference between the magnesium and placebo groups in the median number of leg cramps experienced per week.2 Nevertheless the research simply contained a small number of participants (n=361 in total and n=198 from the subgroup analysis), and therefore has been underpowered to detect meaningful differences between classes. Additionally selection bias could have impacted results as participants were included in the study whose leg ailments might have been confused with ailments known to be related to magnesium deficiency (i.e. restless leg syndrome).

Another Recent systematic review evaluated a further seven research in patients with leg treated with magnesium.12 The elemental magnesium dose given varied between research. inhabitants included 322 mostly older patients and 202 women with pregnancy-associated leg cramps. |} After four weeks of treatment, differences in percentage change from baseline of cramps per week involving magnesium and placebo groups were modest and not statistically significant.

The writers Concluded that magnesium is unlikely to offer a meaningful benefit in reducing the frequency or severity of idiopathic leg cramps in older people.12 The next review also included three further studies on pregnant girls; although a meta-analysis was not possible with them, results in the individual research have been considered and found to be more mixed. 1 study discovered calcium decreased cramp frequency and pain whereas another two found no advantage.12 Although 2 of the research were similar in design and setting,13,14 their results were distinct; this could have been because one of these research lacked baseline dimension of cramp frequency. If cramp frequency before intervention was not comparable between participants in these studies, it isn't appropriate to compare the number of cramps experienced during the treatment period.

Oral magnesium supplementation is well tolerated

The two {Meta-analyses found that magnesium is well taken with the most frequent negative effects affecting the digestive tract (diarrhoea, nausea, vomiting, flatulence and constipation).2,12


Moderate-to-severe {And symptomatic hypermagnesaemia is generally due to excess supplemental intake of magnesium (e.g. as antacids, enemas or by intravenous infusion), most frequently in patients with kidney impairment. |} Be aware of the most common clinical characteristics of moderate-to-severe hypermagnesaemia which are usually neuromuscular (e.g. reduction of deep tendon reflexes, muscle fatigue, gloomy alert state and respiratory depression). Other signs include anorexia, nausea, skin flushing, hypotension, bradycardia/heart block and cardiac arrest.15


When Considering magnesium supplements, make sure patients take a product comprising magnesium just. Some magnesium supplements are combined with potassium and might contribute to hyperkalaemia in people using ACE inhibitors or other medications which cause potassium retention.3 Consider assessing liver function in people using medications that may impair or adversely affect kidney function16 and observe for signs of toxicity.15

Other remedies

Small studies Have demonstrated some benefit from various other medications including diltiazem, gabapentin and vitamin B complex although none can be recommended for muscle cramps due to the poor quality of evidence.6,17-19 Multivitamins and sodium supplementation also have demonstrated benefit in preventing cramps in elderly women, although think about the possible threat of hypertension with sodium supplementation.9 Australian guidelines recommend calcium supplements for leg cramps in pregnant women based on case reports but also highlight there are no controlled trials to support its use.20 Paracetamol may be handy to handle residual muscle pain after cramping.3

Non-pharmacological therapy

Passive Stretch and massage of the affected muscle may relieve cramp and extending the calf muscles daily has been advocated to stop cramp.21 Although there is no clinical trial evidence to support these measures, anecdotal evidence indicates they could succeed and the probability of negative effects is reduced.

Information for patients


Magnesium interacts with other medications |}


Magnesium significantly reduces the absorption of oral bisphosphonates and tetracycline antibiotics and might reduce their activity. |} {
Advise patients to ensure they take these medications at least 2 hours before or after taking a magnesium supplement.22 |}

Median Number of leg cramps experienced per week: Difference = 0.807 (CI 0.015 to 1.207)
Difference In percentage change from baseline of cramps per week: Difference = --3.93% (CI |} --21.12% to 13.26%)